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Orforglipron and retatrutide from Eli Lilly exemplify the next generation of metabolic therapies: oral formulations that promise improved adherence, triple-hormone mechanisms that deliver superior weight loss and expanded therapeutic applications spanning from brain health to renal disease". For 2026, pharma executives must recognize that metabolic innovation extends far beyond replicating existing GLP-1 therapies, the report authors wrote

Taking advantage of the reversibility of Michael addition reaction, we developed the first reversible reaction-based fluorescent probe ThiolQuant Green to perform single-point quantification of GSH in living cells 15

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